Optimum conditions for ursodeoxycholic acid production from lithocholic acid by Fusarium equiseti M41

Preparation of ursodeoxycholic acid from 7-ketone lithocholic acid by stereoselective electroreduction

Background: Ursodeoxycholic acid (UDCA) is an important clinical drug in the treatment of liver disease. In previous work, ursodeoxycholic acid was prepared by traditional organic synthesis. The preparation of ursodeoxycholic acid through an electrochemical method with higher stereoselectivity and environmental friendliness is described herein. Results: Dimethyl sulfoxide (DMSO), dimethylformam...

Production of bile duct hyperplasia and gallstones by lithocholic acid.

Ursodeoxycholic acid

Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem] Indication: The drug reduces cholesterol absorption and is used to dis...

Antibiotic produced by Fusarium equiseti NRRL 5537.

Fusarium equiseti NRRL 5537 grown on an autoclaved white corn grit medium for 3 to 4 weeks at room temperature produced a substance in excess of 5 g/kg of substrate that inhibited some gram-positive bacteria including mycobacteria. Most Bacillus subtilis, Mycobacterium phlei, and Staphylococcus aureus strains were inhibited when 1 mug of the antibiotic per ml was incorporated into the culture m...

Host range and mycotoxin production by Fusarium equiseti isolates originating from ginseng fields1

Fusarium equiseti is prevalent in soil and straw mulch in ginseng (Panax ginseng) fields in British Columbia and causes a reddish brown discolouration on ginseng roots. The pathogenicity of two isolates of F. equiseti from ginseng fields to other plant species belonging to different families was evaluated. Mycelial plugs and spore suspensions were used to inoculate seeds and roots in laboratory...